What are the Roles of Pueraria Tuberosa in Angiogenesis

Pueraria tuberosa is known for its therapeutic potentials in cardiovascular disorders but its effect in angiogenesis not been studied so far. In this study, a computational approach has been applied to elucidate the role of the phytochemicals in inhibition of angiogenesis through modulation of Vascular Endothelial Growth Factor Receptors: VEGFR1 VEGFR2, major factors responsible for angiogenesis. Metabolite structures retrieved from PubChem and KNApSAcK – 3D databases, were docked using AutoDock4.2 tool. Hydrogen bond and Molecular, ADME and toxicity predictions were carried out using UCSF Chimera, LigPlot+ and PreADMET server respectively. From the docking analysis, it was observed that Puerarone and Tuberostan had significant binding affinity for the intracellular kinase domain of VEGFR1 and VEGFR2 respectively. It is important to mention that both the phytochemicals shared similar interaction profile as that of standard inhibitors of VEGFRs. Besides this, both Puerarone an d Tuberostan interacted with Lys861/ Lys868 (ATP binding site of VEGFR1/VEGFR2), thus providing a clue that they may enforce their inhibitory effect by blocking the ATP binding domain of VEGFRs. Moreover, these molecules exhibited good drug-likeness, ADME properties without any carcinogenic and toxic effects. The interaction pattern of the Puerarone and Tuberostan may provide a hint for a novel drug design for VEGF tyrosine kinase receptors with better specificity for the treatment of Angiogenic

The Museum Of Outdoor Arts - 944 Words

John Madden and his daughter, Cynthia Madden Leitner founded the Museum of Outdoor Arts (MOA) in 1981. When the museum first opened, there were nineteen art acquisitions on display, all public outdoor sculptures, establishing the mission statement of â€Å"making art a part of everyday life.† The first building the MOA offices resided in was Orchard Falls in Greenwood Village; since then, the museum moved four or five times within the Arapahoe county. Currently, the Museum of Outdoor Arts occupies a space in the Englewood Civic Center on the second floor across from the courts. In 2000, MOA moved from Greenwood Village to Englewood, incorporating indoor galleries, offices, and a workshop studio into the new location. Five to six staff members run the museum, hiring interns and independent contractors as needed. A board of trustees and an advisory committee guide the policies of the museum and make legal decisions. The board of trustees has four members consisting of the Presi dent of the Board, the Vice President, the Treasurer, and the Secretary, while the advisory committee has eight members. The museum curates and manages over 200 art pieces within its collection. The museum acquires at least one new art piece a year to exhibit in one of the public locations the museum manages. Marjorie Park in Greenwood Village and the Englewood Civic Center Sculpture Garden are the two main sites for MOA to exhibit acquisitions and large pieces from the collection. Marjorie Park, formallyShow MoreRelatedEducating Volunteer For 5 Hours1494 Words   |  6 PagesBruce Museum. I remembered that I volunteered once at the Bruce Museum with my cousins, but I couldn’t remember much of what I did because I volunteered a long time ago. So I thought that this would be a great place for me to volunteer again, and this time I knew I would remember what I did. The Bruce Museum was a great place for me to volunteer, it gave me a great opportunity to talk to some of the artists and really get to know them and their artwork. At first it doesn’t seem like an Arts FestivalRead MorePhilad elphi The United States1183 Words   |  5 Pagesregion consisting of many neighborhoods. Center City Philadelphia and the surrounding Philadelphia Neighborhoods contain some of the most sought after Philadelphia Real Estate Listings in the city. Center City Philadelphia Neighborhoods include: The Art Museum Area, Bella Vista, Queen Village, Washington Square West, Society Hill, Graduate Hospital, Point Breeze, Southwest Center City, Midtown Village, Fishtown, Manayunk, University City, Rittenhouse Square, Old City, Fitler Square, Logan Square, andRead MoreComparative Criticism of Two Museums1211 Words   |  5 PagesMark Moran Prof. Elizabeth Marlowe Masterpieces of Western Art November 8, 1999    Formal Comparison of Two Museums The Frick Collection and The Guggenheim Museum are both museums on 5th  Avenue in New York’s Upper East Side neighborhood, and they are both named for famous American tycoons from the early 20thcentury.   But their similarities pretty much end there.   The Frick Collection is the former residence of steel baron Henry Clay Frick who spent forty years assembling a large collection ofRead MoreComparative Criticism of Two Museums1221 Words   |  5 PagesMark Moran Prof. Elizabeth Marlowe Masterpieces of Western Art November 8, 1999    Formal Comparison of Two Museums The Frick Collection and The Guggenheim Museum are both museums on 5th  Avenue in New York’s Upper East Side neighborhood, and they are both named for famous American tycoons from the early 20thcentury.   But their similarities pretty much end there.   The Frick Collection is the former residence of steel baron Henry Clay Frick who spent forty years assembling a large collection of artworkRead MorePersonal Statement For Purpose965 Words   |  4 PagesUniversity of Leicester Museum Studies’ Jobs Desk for a London Coordinator (Sculpture) for Art UK Sculpture. As a passionate supporter of our national and regional cultural heritage, I thoroughly enjoy working with objects, ideas and stories, inspiring other to engage with art. I have long-standing knowledge of London, having lived - in North, South and West London - and worked in the Capital for many years, and I am familiar with many of London’s diverse galleries and museum collections. The positionRead MoreThe Wadsworth Athenaeum Of Art1419 Words   |  6 PagesThe Wadsworth Athenaeum of Art has been in existence since 1842. Located in Hartford, Connecticut, it is the nation’s oldest public art museum. The founder, Daniel Wadsworth, was a world-renowned art patron who acquired many famous works that would put his museum at the forefront of all its competitors. The museum has a impeccable reputation as a leader for innovation and experimentation due to its previous Director, A. Everett â€Å"Chick† Austin, Jr. Austin always pushed the envelop by continuing toRead MoreEssay On Exploring Washington State With Kids1239 Words   |  5 Pageshome to Washington’s oldest brick building (built in 1858). Bests of all, there’s a lot to do in the city center for families including the SPARK Museum of Electrical Invention which contains hands-on science exhibits. The Whatcom Museum showcases art, nature and regional history. If time permits, pay a visit to Fairhaven, a neighborhood filled with art galleries, toy shops, ice-cream shops, bookstores, and boutiques. Where to eat: Game-playing families need to dine at a new restaurant called RookRead MorePost-impressionism and Artists1298 Words   |  6 Pagesdespite criticism from the conventional art community in France. The movement received its name from one of the movements most now most recognized artists Claude Monet and his piece Impression, Sunrise. It is said that a critic accused the painting of being a sketch or â€Å"impression†. (Samu, 2004) Paintings of this period tended to be outdoor scenes and panoramas. My Grandfather, Lawrence Bird, who was an artist and set designer for Disney modeled his style of art after this period. He was inspiredRead MoreDescriptive Essay About Southwestern Quebec931 Words   |  4 Pagesthe most iconic landmarks and spirited events in the country. There are plenty of outdoor thrills, amazing architecture, annual festivals, and cultural richness at every corner. From the Eastern Townships practically rubbing shoulders with Vermont and New Hampshire to a bustling city like Montreal and scenic Laurentian Mountains, Southwestern Quebec is certainly a crowd pleaser. Countryside farms, historic museums, unique basilicas, and national parks including Lafontaine Park and the well-visitedRead MoreClaude Monet and Impressionism1107 Words   |  4 Pagesbeside Claude Monet. But in this composition we will talk more about Claude Monet because he was the founder of Impressionism in the world. Oscar Claude Monet was the founder of impressionism. He is a famous french painter whose work gave a name to the art movement impressionism. Claude Monet’s famous quote is â€Å"merely think here is a little square of blue, here an oblong (having an elongated shape, as a rectangle or an oval) of pink, here a streak of yellow and paint it just as it looks to you, the exact

Political Cartoon Essay Free Essays

In this cartoon Luckovic shows how President Barrack Obama holds only one piece of candy only for a huge crowd of kids outside of his house. In this case the piece of candy is catalogued as a job opportunity. All the kids appear to have a worried face, doubting that they will get something for this Halloween night. We will write a custom essay sample on Political Cartoon Essay or any similar topic only for you Order Now On the other hand, president Obama looks like he is frustrated and not satisfied by only having this one piece of candy for all the disappointed kids. It is also good to mention that all the kids have their candy bag open as if they are expecting to receive something even though there is only one piece of candy, even though it appears that only one kid is going to be fortunate enough to receive a treat that occasion. This cartoon shows how difficult the employment situation is at the moment due to the economic recession. It also reflects on the amounts of people that has lost their jobs and are waiting for a miracle from president Obama. Obviously Luckovic is disappointed with the government because it has been 10 months since president Obama took charge in January and there hasn’t been a real big improvement on the economy. In the cartoon Luckovic how president Obama holds a big bowl with the purpose of showing how years ago that bowl was big because there were actually jobs available. Obama’s ears are also big and open in this cartoon, trying to demonstrate how the president is very attentive when it comes to the people. In the crowd you might see characters such as a cowboy, a football player and Mickey mouse, all of these being important economic powerhouses struggling nowadays. Another important character in the back is Santa Claus with a worried face, demonstrating how Christmas time is rapidly approaching and there is a lack of funds available that are not going to be able to fulfill people’s wishes this December. Cartoon cited Luckovich, Mike. Cartoon. 7 Oct. 2009. 27 Oct. 2009. http://www. creators. com/editorialcartoons/mike-luckovich/10945. html . Valzania, Gilberto MW 7am How to cite Political Cartoon Essay, Essays